M. R. Gonalves1,
Simon Walker-Samuel1, Sean Peter Johnson2, Rosamund
Barbara Pedley2, Mark F. Lythgoe1
1UCL
Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of
Child Health, London, United Kingdom; 2UCL Cancer Institute,
London, United Kingdom
Solid tumours have been found to exhibit fluctuating patterns of hypoxia-reoxygenation, which contribute to resistance to chemotherapy and radiotherapy, as well as being associated with a more aggressive phenotype. We present an Independent Component Analysis (ICA)-based approach to identify the contribution of systemic changes in blood oxygenation on tumour fluctuations and separate them from those which are specific to the tumour. We performed a comparison between two colorectal tumour xenograft models with differing vascular characteristics.