T2-Weighted and DCE MRI of Medulloblastoma Mouse Model and Oncolytic Measles Virus

Anna Bratasz¹, Adam Studebaker², Corey Raffel¹, Kimerly A. Powell¹

Medulloblastomas are the most common childhood brain cancer. They account for 15-20% of all pediatric brain tumors. It is a highly invasive tumor with a poor prognosis in a subset of patients. The goal of this study was to monitor the treatment effect of an oncolytic measles virus (MV) in a medullablastoma tumor model using T2-weighted and DCE-MR imaging. This data indicates that MV was successful in reducing the primary tumor, and that no difference in the perfusion properties measured using DCEMRI were observed in mice treated with MV combined with endostatin/angiostatin fusion protein from that of MV only.