Abstract #1635

In Vitro DTI Assessment of Muscle Architecture in Osteoporotic and Osteoarthritic Subjects: A Preliminary Study.

Giulia Di Pietro¹,², Marco Palombo³,⁴, Jacopo Baldi⁵, Eleonora Piccirilli⁵, Monica Celi⁵, Umberto Tarantino⁵, Silvia Capuani⁶,⁷

¹IIT@Sapienza, Physics Department, Sapienza University, Roma, Rome, Italy; ²Physics Department, Sapienza University, Rome, Italy; ³Physics Department, Sapienza University , Rome, Italy; ⁴CNR IPCF UOS Roma, Physics Department, Sapienza University, Rome, Italy; ⁵Department of Orthopaedics and Traumatology, University of Rome Tor Vergata,, Roma, Italy; ⁶Sapienza University, Rome, Italy; ⁷CNR IPCF UOS Roma, Physics Department, Sapienza University , Rome, Italy

Aim of this study was to investigate the microstructural features in muscles of osteoporotic(OP) and osteoarthritic(OA) women with DTI. Our in vitro preliminary results highlight that FA is lower in OP when compared to OA. As a consequence OP muscle has a more isotropic microstructure compared to that of OA muscle. Moreover MD, and radial diffusivity are lower in OA compare to OP, while no differences was found in axial diffusivity. These results are in agreement with previous histological results obtained in OP muscles in which type II fibers atrophy occurs, with a consequent enlargement of water spaces between fibers.