Mary Kate Manhard1,
2, R. Adam Horch1, 2, Kevin D. Harkins2,
Daniel F. Gochberg, 23, Jeffry S. Nyman4, Mark D. Does1,
2
1Biomedical
Engineering, Vanderbilt University, Nashville, TN, United States; 2Vanderbilt
University Institute of Imaging Science, Vanderbilt University, Nashville,
TN, United States; 3Radiology & Radiological Sciences,
Vanderbilt University, Nashville, TN, United States; 4Department
of Orthopaedics & Rehab, Vanderbilt University, Nashville, TN, United
States
MRI methods have been developed to image cortical bone using T2-selective magnetization preparation pulses to discriminate between pore water and water bound to collagen in bone. Previous work has shown that CPMG non-imaging methods correlate with the amount of bound and pore water in bone. This work validates imaging methods against the CPMG non-imaging methods using pieces of cortical bone from the same sample. The imaging was validated at 4.7T and 3T with clinically practical parameters. The results show promise for clinically useful methods to quantitatively assess bound and pore water in bone.