MRI Texture Analysis for Preoperative Staging of Renal Cell Cancer

Andrea S. Kierans¹, Henry Rusinek¹, Andrew Lee, William C. Huang², Hersh Chandarana¹

Renal cell cancer (RCC) stage has important prognostic and treatment implications. It is not possible to reliably stage RCC on pre-operative conventional imaging. In this study we assessed tumor signal characteristics and lesion texture in 65 RCCs who underwent MRI before resection. There were no significant difference in lesion signal characteristics, however, there were differences in second order texture parameters between low and high stage RCC. Textural differences in ADC and post-contrast exam correctly discriminated 92% of these tumors. Future work is needed to validate size and texture model on an independent cohort to predict preoperative RCC stage.