Susanne Bonekamp1,
David Bonekamp1, Vivek Gowdra Halappa2, Jean Francois
Geschwind2, John Eng2, Celia Pamela Corona-Villalobos1,
Diane Reyes2, Timothy M. Pawlik3, Ihab R. Kamel2
1Radiology,
Johns Hopkins University, Baltimore, MD, United States; 2Radiology,
JHU, Baltimore, MD, United States; 3 Surgery, JHU, Baltimore, MD, United States
One metric that reflects the quality of data collected in clinical studies is the interobserver agreement of a proposed method. In this study we investigated the interobserver agreement of three different approaches used to obtain functional, volumetric and morphologic MRI-based parameters of response to loco-regional treatment in patients with unresectable Hepatocellular Carcinoma. As hypothesized, semi-automated, volumetric analysis of tumor size, tumor enhancement and ADC values resulted in higher interobserver agreement compared to manual ROI-based analysis of the same parameters