Samantha Flood1,
Eric Meng2, Melanie Beaton3, Lanette J. Friesen-Waldner4,
Congyu Zhang5, Charles A. McKenzie1
1Medical
Biophysics, The University of Western Ontario, London, Ontario, Canada; 2Schulich
School of Medicine and Dentistry, The University of Western Ontario, London,
Ontario, Canada; 3Department of Medicine, The University of
Western Ontario, London, Ontario, Canada; 4Medical Biophysics,
University of Western Ontario, London, Ontario, Canada; 5Engineering,
The University of Toronto, Toronto, Ontario, Canada
Non-Alcoholic Fatty Liver Disease (NAFLD) is the leading form of liver disease worldwide in both adults and children. Forty-five patients with confirmed NAFLD underwent multiple MRIs and biopsies. Proton Density Fat Fraction was calculated from IDEAL MRI and area fat fraction was calculated from digitised biopsy samples. Results from two raters were compared to determine reproducibility of the MRI and biopsy derived fat fractions. Fat fractions determined by biopsy and MRI correlate strongly and have similarly high inter-rater reproducibility. These results suggest that MRI is a good non-invasive option for quantifying hepatic fat.