Prospectively and Retrospectively Gated Lung MR Imaging Sequences Compared for Visualizing Pneumonial Cryptococcosis

Tom Dresselaers¹, Greetje Vande Velde¹, Jennifer Poelmans¹, Arno Nauerth², Eric Verbeken¹, Katrien Lagrou³, Uwe Himmelreich¹

Cryptococcus neoformans and C. gattii are encapsulated yeasts that cause life-threatening disease that affect the lungs and may spread to the brain. As symptoms appear only after the disease manifestation at a very late stage, it is essential to dynamically monitor cryptococcosis non-invasively to establish the infection kinetics and potential spreading to the CNS on an individual basis. Although CT can be used with good spatial resolution, the soft tissue contrast is limited and radiotoxicity concerns limit the applicability in longitudinal studies. Therefore, we have aimed at evaluating different MRI protocols to visualize lung infection in a mouse model for pneumonial cryptococcosis.