Abstract #1480

MRI Equilibrium Signal Mapping Is a Quantitative and Reproducible Alternative to CT for the Estimation of Lung Density in COPD

Weijuan Zhang¹,², Penny L. Hubbard¹,², Eva Bondesson³, Lars Wigstrm⁴, Simon S. Young⁵, David Singh⁶, Josephine H. Naish¹,², Geoffrey J. M. Parker¹,²

¹Centre of Imaging Sciences, The University of Manchester, Manchester, United Kingdom; ²Biomedical Imaging Institute, The University of Manchester, Manchester, United Kingdom; ³Camurus AB, Lund, Sweden; ⁴Respiratory &Inflammation Therapy, Clinical development, AstraZeneca, Mlndal, Sweden; ⁵Personalised Healthcare and Biomarkers, AstraZeneca, Alderley Park, United Kingdom; ⁶Medicines Evaluation Unit, University Hospital of South Manchester Foundation Trust, Manchester, United Kingdom

This study demonstrated a good correlation between MRI equilibrium signal maps and CT measurements in the estimation of lung density in COPD.