Damien Pike1,
2, Miranda Kirby1, 2, Andrew Wheatley1,
David G. McCormack3, Grace Parraga1, 2
1Imaging
Research Laboratories, Robarts Research Institute, London, Ontario, Canada; 2Department
of Medical Biophysics, The University of Western Ontario, London, Ontario,
Canada; 3Division of Respirology, Department of Medicine, The
University of Western Ontario, London, Ontario, Canada
Our objective was to register a three-dimensional (3D) computed tomography (CT)-derived airway tree with hyperpolarized helium-3 (3He) magnetic resonance imaging (MRI) to gain a better understanding of the etiology of MRI ventilation defects. CT airway tree models and 3He MRI models were constructed and registered using volumetric fiducial registration. Regions of ventilation defects and the airways leading into these regions can be visualized in 3D using the CT-MRI registered model. Future work will be focused on tracing specific airway paths into ventilation defect regions. This will allow us to evaluate the alterations in airway morphology that occur in lung disease.