Mu He1, 2,
Suryanarayanan S. Kaushik1, 3, Matthew S. Freeman4,
Rohan S. Virgincar1, 3, Scott H. Robertson1,
John Davies5, Jane Stiles5, William Michael Foster5,
H. Page Mcadams6, Bastiaan Driehuys, 34
1Center
for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United
States; 2Department of Electrical and Computer Engineering, Duke
University, Durham, NC, United States; 3Department of Biomedical
Engineering, Duke University, Durham, NC, United States; 4Center
for In Vivo Microscopy, Duke University, Durham, NC, United States; 5Department
of Medicine Pulmonary, Duke University Medical Center, Durham, NC, United
States; 6Department of Radiology, Duke University Medical Center, Durham,
NC, United States
Clinical hyperpolarized 129Xe has shown significant progress recently but scan logistics and cost remain constrained by the need for large volumes of 129Xe. This could be addressed by using lower volumes of 129Xe, but doing so requires understanding the limits this imposes on the ability to quantify the images as well as the value of different acquisition strategies. In this work, we evaluate subtle ventilation defects seen in older healthy volunteers using two dose volumes (1L and 300ml) with both a multi-slice GRE and 3D radial pulse sequence.