Abstract #1395

Arrhythmia Insensitive Rapid Cardiac T1 Mapping Pulse Sequence: In Vitro Study

Michelle Fitts¹,², Elodie Breton³, Eugene G. Kholmovski²,⁴, Derek J. Dosdall²,⁵, Sathya Vijayakumar,²⁴, Kyung P. Hong¹,², Ravi Ranjan²,⁵, Nassir F. Marrouche²,⁵, Leon Axel⁶, Daniel Kim²,⁴

¹Bioengineering, University of Utah, Salt Lake City, UT, United States; ²CARMA Center, University of Utah, Salt Lake City, UT, United States; ³ICube, Strasbourg University, Strasbourg, Alsace, France; ⁴UCAIR, Department of Radiology, University of Utah, Salt Lake City, UT, United States; ⁵Internal Medicine, University of Utah, Salt Lake City, UT, United States; ⁶Department of Radiology, New York University, New York, United States

We present a cardiac T1 mapping pulse sequence based on saturation recovery, which is arrhythmia-insensitive and rapid (AIR) for assessment of diffuse fibrosis. We compared its performance against the conventional cardiac T1 mapping inversion recovery based method, MOLLI, which is sensitive to heart rate and rhythm conditions, using an IR fast spin-echo sequence for reference. In vitro studies demonstrated that T1 measurements made by AIR were more precise and accurate than MOLLI at different heart rate and rhythm conditions. More work is needed to validate diagnostic accuracy and precision in patients with tachycardia and/or arrhythmias.