Mohammed Suhail1,
2, Mark W. Wilson1, Steven W. Hetts1, Robert F.
Mattrey3, Maythem Saeed1
1Department
of Radiology, University of California San Francisco, San Francisco, CA,
United States; 2School of Medicine, University of California San
Diego, La Jolla, CA, United States; 3Department of Radiology,
University of California San Diego, La Jolla, CA, United States
This MRI study was designed to compare phasic, peak strain and time to peak strain after acute myocardial infarction caused by LAD coronary microembolization and occlusion/reperfusion. The infarct size on delayed contrast enhanced MRI was significantly smaller in animals subjected to microembolization compared to LAD occlusion/reperfusion. Microemboli and LAD occlusion significantly decreased peak strain when compared to remote myocardium. However, the difference in peak strain between interventions was not significant. The pattern of myocardial infarct plays a role in ventricular synchronization. Furthermore, there is disproportion between infarction size and circumferential strain in animals subjected to microembolization and LAD occlusion/reperfusion.