Kieren Grant Hollingsworth1,
Kate Hallsworth2, Christian Thoma2, Djordje G.
Jakovljevic2, Guy A. MacGowan3, Quentin Anstee1,
Andrew M. Blamire1, Roy Taylor1, Chris P. Day1,
Michael I. Trenell2
1Institute
of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and
Wear, United Kingdom; 2MOVElab, Newcastle University, Newcastle upon
Tyne, Tyne and Wear, United Kingdom; 3Institute of Genetic
Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United
Kingdom
Non-alcoholic fatty liver disease (NAFLD) is associated with a twofold greater risk of developing cardiovascular disease than those witout. Little is known about the early cardiac alterations in NAFLD, limiting our ability to identify therapeutic strategies. This study aimed to define the effect of NAFLD on cardiac morphology, function and metabolism in a representative group of 19 subjects using MRI imaging, cardiac tagging and phosphorus spectroscopy. NAFLD patients had significantly thicker LV walls, with reduced longitudinal shortening. Peak torsion was unaltered but peak strain at the endocardial wall was increased. PCr/ATP ratio was not reduced, unlike the previous young male study.