High Temporal Resolution, Simultaneous Quantification of Intravascular Blood Flow and Oxygen Saturation with BRISK K-Space Sampling

Zachary Rodgers¹, Lohith Kini¹, Varsha Jain¹, Michael C. Langham¹, Jeremy F. Magland¹, Felix W. Wehrli¹

A dual-echo phase contrast pulse sequence with BRISK k-space sampling was used to quantify intravascular blood flow and oxygen saturation (%HbO₂) simultaneously at 2 s temporal resolution. BRISK sampling was shown to have improved motion sensitivity compared to keyhole as well as improved ability to resolve changes in blood flow and %HbO₂ during dynamic physiologic paradigms in both the cerebral and peripheral veins. Applications of this pulse sequence include high temporal resolution quantification of cerebral metabolism and evaluation of peripheral artery disease in response to post-occlusion reactive hyperemia in the leg.