Abstract #1204

Chronic Exposure of Neurotoxic Doses of D-Amphetamine Potentiates the Central Effect of an Acute Challenge with Methylphenidate.

A. Schrantee¹,², J.L. Tremoleda², M. Wylezinska-Arridge², W. Gsell², L. Reneman¹

¹Academic Medical Center, Amsterdam, Netherlands; ²MRC Clinical Sciences Centre, Biological Imaging Centre, London, United Kingdom

This study assesses whether phMRI is a valid tool to study the sensitivity to study moderate DA dysfunction. To this end we administered dAMPH chronically and assessed the BOLD response to a MPH challenge.