Abstract #1192

High Resolution Mapping of Modafinil Induced Changes in Glutamate Level in Rat Brain

Mohammad Haris¹, Anup Singh¹, Kejia Cai¹, Kavindra Nath², Feliks Kogan¹, Hari Hariharan¹, John A. Detre¹, C Neill Epperson³, Ravinder Reddy¹

¹CMROI, Radiology, University of Pennsylvania, Philadelphia, PA, United States; ²Molecular Imaging, University of Pennsylvania, Philadelphia, PA, United States; ³Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

Modafinilis used for the treatment of narcolepsy and somnolence and is known to increase cerebral glutamate (Glu) levels. We used the GluCEST technique to measure modafinil induced Glu changes in rat brain and compared the results with Glu concentration by proton magnetic resonance spectroscopy (MRS). No immediate increases in either GluCEST or Glu concentration were observed after modafinil injection, but a significant increase in both GluCEST (194.4%) and MRS Glu concentration (224.9%) was observed 24 hours after modafinil administration.