Tianye Zhai1,
2, Tianye Zhai3, Chunming Xie1, 2,
Zheng Yang1, Shi-Jiang Li2
1Center
of Brain and Cognition, Beijing Institute of Basic Medical Science, Beijing,
China; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI,
United States; 3Biomedical Engineering, Chinese Academy of Medical
Sciences & Peking Union Medical College, Beijing, China
Neurobiological and neuroimaging studies have demonstrated that the ventral medial prefrontal cortex (vmPFC), a major node for decision making, is crucial in drug addiction. 1,2 However, little is known about the role of the vmPFC network and its relation to drug-seeking behaviors, such as impulsivity in addiction. In this study, we utilized resting-state functional connectivity fMRI (R-fMRI) to investigate the alteration of the vmPFC network and its relationship to impulsivity in abstinent heroin dependent subjects (HD) and control nondrug users (CN).