Abstract #1107

Hippocampal Volume Relates to White Matter Integrity and Episodic Memory in Multiple Sclerosis

Katherine A. Koenig¹, Ken E. Sakaie¹, Mark J. Lowe¹, Jian Lin¹, Lael Stone², Robert A. Bermel³, Erik B. Beall¹, Stephen M. Rao², Bruce D. Trapp⁴, Micheal D. Phillips¹

¹Imaging Sciences, Cleveland Clinic, Cleveland, OH, United States; ²Neurological Institute, Cleveland Clinic, Cleveland, OH, United States; ³Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States; ⁴Neurosciences, Cleveland Clinic, Cleveland, OH, United States

The current study compares hippocampal atrophy to episodic memory measures and to diffusion measures of the fornix in patients with Multiple Sclerosis. Though we find no differences in overall hippocampal volume between patients and controls, measures of white matter integrity in the fornix and a measure of episodic memory were related to hippocampal volume only in patients. This bolsters the argument that hippocampal pathology contributes to memory loss in MS.