Huijun Liao1,
Sai K. Merugumala2, Shahamat Tauhid3, Rohit Bakshi3,
Alexander Lin2
1Center
for Clinical Spectroscopy , Brigham and Women's Hospital, Boston, MA, United
States; 2Center for Clinical Spectroscopy, Brigham and Women's
Hospital, Boston, MA, United States; 3Laboratory for Neuroimaging
Research, Department of Neurology, Brigham and Women's Hospital, Boston, MA,
United States
Glutathione (GSH) is as a marker for oxidative stress that may be reflective of inflammation in multiple sclerosis (MS). The goal of this study is to determine the feasibility of GSH measurement in MS patient and controls using widely available 3T single voxel 1H MRS and LCModel analysis. We also determined the optimal voxel placement for GSH measurements. Our results show GSH can be quantitatively and accurately measured using single voxel 1H MRS and LCModel analysis and anterior cingulate gyrus and superior temporal white matter are the ideal voxel locations for GSH measurements.