Gregory H. Turner1,
Qingwei Liu1, Shannon L. Olfers2, Garilyn M. Jentarra3,
Sampathkumar Rangasamy2, Vinodh Narayanan2
1Neuroimaging
Research, Barrow Neurological Institute, Phoenix, AZ, United States; 2Developmental
Neurogenetics Research, Barrow Neurological Institute, Phoenix, AZ, United
States; 3Biochemistry, Midwestern University, Glendale, AZ, United
States
Mutations of the gene MeCP2 have been shown to cause Rett syndrome and are associated with other neurodevelopmental disorders such as autism and X-linked mental retardation. These mutations result in altered dendrite pathology and abnormal fine dendrite structure. DTI was used to measure alterations in FA in cortical gray matter in WT and MeCP2-A140V mutant mice and to evaluate its potential as a non-invasive biomarker of dendritic branching complexity.