Hunter R. Underhill1,
Robert C. Rostomily1
1Neurological
Surgery, University of Washington, Seattle, WA, United States
We present a method for quantitatively measuring the voxel-based blood-brain barrier permeability associated with glioblastoma multiforme in the in vivo rat brain at 3.0 T using a continuous infusion of gadolinium. The technique is based on a simplification of the Brix method and yields ktrans-maps after accounting for pixel-based variations in R1 and B1.