Laminar Specific Detection of Amyloid Precursor Protein -Induced Neurodegeneration and Recovery Using MEMRI in an Olfactory Based Alzheimers Disease Mouse Model.

Galit Saar¹, Ning Cheng², Leonardo Belluscio², Alan P. Koretsky¹

MEMRI was used to detect specific laminar changes in olfactory bulb (OB) to follow the progression of APP-induced neuronal pathology and its recovery in a reversible olfactory-based AD mouse model. OB volume and manganese enhancement of the glumerular layer in OB were decreased dramatically in mutant mice. Turning off APP overexpression with doxycycline, resulted in an increase in manganese enhancement of the glomerular layer after only 1 week, with farther recovery after 3 weeks. Moreover, APP antibody treatment showed an increase enhancement in the treated OB and demonstrate the potential of MRI in this mouse model to assess neuroprotective strategies.