Weiqi Liao1,
2, Xiaojing Long1, 2, Chunxiang Jiang1,
2, Yanping Chen3, Lijuan Zhang1, 2
1Paul
C Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of
Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong
Province, China; 2Shenzhen Key Laboratory for MRI, Shenzhen
Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen,
Guangdong Province, China; 3Industry Development Department,
Shenzhen National High-tech Industrial Innovation Center, Shenzhen, Guangdong
Province, China
This study tried to find objective evidences for mild cognitive impairment (MCI) subjects reverted to normal cognitive status during the follow-up visits in ADNI cohort. Bilateral hippocampal volumes, atrophy rate of bilateral temporal lobe, concentration of T-tau and A1-42 in cerebrospinal fluid and MMSE scores were selected as biomarkers. The changes of all biomarkers except MMSE scores during the reversion in 12 month were statistically insignificant. Longer follow-up with greater sample size can better characterize the dynamic of MCI reversion, which can provide vital information for possible treatment and disease management.