Abstract #0992

Relaxation, Magnetization Transfer, and Diffusion Tensor Measurements in the Hippocampal Formation of APP and PS1 Transgenic Mice

Jonathan D. Thiessen¹,², Kerrie Hayes³, Melanie Martin,²⁴

¹Radiology, University of Manitoba, Winnipeg, Manitoba, Canada; ²Physics & Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada; ³Biology, University of Winnipeg, Winnipeg, Manitoba, Canada; ⁴Physics, University of Winnipeg, Winnipeg, Manitoba, Canada

T₁ and T₂ relaxation, diffusion tensor imaging, and quantitative magnetization transfer imaging was applied to ex vivo APP and PS1 mice, with a focus on the hippocampal formation. Structures in the hippocampal formation were visible in diffusion anisotropy maps, allowing regions of interest to be defined and measured for all of the quantitative MRI measurements. This work represents a first step towards multimodal MRI measurements in mouse models of Alzheimer's disease.