Lawrence Kenning1,
Martin Lowry1, Ralph Noeske2, Lindsay W. Turnbull1
1Centre
for MR Investigations, Hull York Medical School at University of Hull, Hull,
East Yorkshire, United Kingdom; 2EMEA Research and Collaboration,
, Applied Science Laboratory, GE Healthcare, 10587 Berlin, Germany
Lactate concentration in gliomas is a potential biomarker for tumour behaviour and treatment response. To investigate this we implemented a PRESS MRSI editing sequence with BASING pulses and interleaved frequency offsets to reduce motion effects. Broadband refocusing pulses reduced chemical-shift displacement thus improving editing efficiency. Semi-automated processing generated separate singlet and edited spectra that were processed using LCModel. In 16 patients we observed lactate in 5 of 7 high-grade lesions, where it accounted for 33-60% of the resonance at 1.3ppm with concentrations of 1.7-6.0mM. The sequence will allow investigation of relationships between lactate concentration, tumour heterogeneity and treatment response.