Abstract #0955

Amide Proton Transfer Imaging of Diffuse Gliomas: Correlation with Histopathological Grades

Osamu Togao¹,², Takashi Yoshiura², Jochen Keupp³, Akio Hiwatashi², Koji Yamashita², Kazufumi Kikuchi², Yuriko Suzuki⁴, Mariya Doneva³, Koji Sagiyama⁵, Masaya Takahashi⁵, Hiroshi Honda²

¹Molecular Imaging and Diagnosis, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan; ²Clinical Radiology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan; ³Philips Research Europe, Hamburg, Germany; ⁴Philips Electronics Japan, Minato-ku, Tokyo, Japan; ⁵Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Amide proton transfer (APT) imaging employs the exchange between protons of free tissue water and the amide groups (-NH) of endogenous mobile proteins and peptides, imaged by a chemical exchange saturation transfer technique. APT imaging is expected to be a non-invasive method to measure proteins and peptides level in active tumors. In this study, we demonstrated the ability of APT imaging for prediction of histopathological grades of diffuse gliomas in a large patient population with histopathological evaluations.