Dirk Ernst Cleppien1,
2, Lei Zheng3, Claudia Falfan-Melgoza1, Barbara
Vollmayr2, 4, Gabriele Ende5, Wolfgang
Weber-Fahr1, 5, Alexander Sartorius, 12
1RG
Translational Imaging, Central Institute of Mental Health, Medical Faculty
Mannheim/ Heidelberg University, Mannheim, Germany; 2Department of
Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical
Faculty Mannheim/ Heidelberg University, Mannheim, Germany; 3Experimental
Radiation Oncology, University Medical Center Mannheim, Heidelberg
University, Mannheim, Germany; 4Research Group Animal Models in
Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/
Heidelberg University, Mannheim, Germany; 5NeuroImaging, Central
Institute of Mental Health, Medical Faculty Mannheim/ Heidelberg University,
Mannheim, Germany
One idea to measure possible neuroplastic effects of the brain is magnetic resonance imaging by using techniques like voxel-based morphometry (VBM). One possible drawback could be sensitivity to reversible changes of the brain structure as measurable by regional cerebral blood volume (rCBV). Therefore, our hypothesis was that rCBV partially explains the variance of VBM changes, which we tested by analyzing region-based correlations between rCBV and VBM in rat brain. For large brain regions rCBV correlates significantly with gray matter probability maps, whereas white matter probability maps correlate negatively with rCBV.