Abstract #0922

Non-Invasive Regional Brain Temperature Measurements During and After Hypothermia Therapy in Newborns with Suspected Hypoxic/ischemic Brain Injury

Tai-Wei Wu¹, Ida Ashoori²,³, Jessica L. Wisnowski², Marvin D. Nelson², Thomas G. Perkins⁴, Jonathan M. Chia⁴, Ashok Panigrahy⁵, Stefan Blml²,³

¹Neonatology, Children's Hospital Los Angeles, Los Angeles, CA, United States; ²Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States; ³Rudi Schulte Research Institute, Santa Barbara, CA, United States; ⁴Philips Healthcare, Cleveland, OH, United States; ⁵Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States

This study uses non-invasive MR spectroscopy to measure regional brain temperatures during and after hypothermia therapy (HT) in newborns with suspicion for hypoxic ischemic encephalopathy. The goal of the study was to determine whether HT is effective in lowering brain temperature, to explore regional differences, and to determine to what extent esophageal/rectal temperatures correlate with brain temperatures. The long-term goal is to use this information to tailer HT to the needs of individual patients.