Mohammad Sabati1,
Sulaiman Sheriff1, Meng Gu2, Henry Zhu3,
Peter B. Barker3, Daniel Spielman2, Andrew A. Maudsley1
1Radiology,
University of Miami, Miami, FL, United States; 2Radiology,
Stanford University, Stanford, CA, United States; 3Radiology, Johns
Hopkins University, Baltimore, MD, United States
MR spectroscopic imaging (MRSI) offers considerable potential for detection of alterations in tissue metabolism; however, the use of current techniques for clinical studies and multi-center trials remains limited due to variability of implementations across sites and manufactures scanners; restrictive implementations in terms of the spatial extent over which data is obtained; and relative complexity of the data analysis. To address these limitations a standardized volumetric whole-brain 1H MRSI sequence has been implemented on scanners from three different manufacturers at three sites and combined with a fully automated MRSI processing procedure. Results were compared using a spectroscopic phantom and thirty aged-matched normal subjects.