Abstract #0784

Clinical Utility of NODDI in Assessing Patients with Epilepsy Due to Focal Cortical Dysplasia

Gavin P. Winston¹, Mark R. Symms¹, Daniel C. Alexander², John S. Duncan¹, Hui Zhang²

¹Epilepsy Society MRI Unit & Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom; ²Department of Computer Science & Centre for Medical Image Computing, University College London, London, United Kingdom

NODDI (neural orientation dispersion and density imaging) is a multi-compartment diffusion model that can distinguish two key variables contributing to FA changes - neurite density and orientation dispersion - with a clinically feasible scan protocol (20 minutes).