1Radiology,
Washington University in St. Louis, Saint Louis, MO, United States; 2Departments
of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United
States; 3Neurology, Washington University in St. Louis, Saint
Louis, MO, United States; 4Hope Center of Neurological disorders,
Washington University in St. Louis, Saint Louis, MO, United States
Diffusion tensor imaging (DTI) has been successfully used to quantify directional diffusivities of coherent white matter tracts and perform tractography. However, DTI cannot model crossing fibers and subvoxel partial volume effect due to increased cellularity and extra-cellular space. Diffusion basis spectrum imaging (DBSI) has recently been proposed to overcome DTI limitations. Preliminary phantom and animal studies have suggested that DBSI not only resolved crossing fibers, but also computed directional diffusivities of each crossing fiber and quantified subvoxel partial volume effect. In this study, we reported the first application of DBSI to normal human brain and demonstrated DBSI utilities mapping white matter connectivity and quantifying multiple diffusion components along fiber tracts.