Abstract #0763

Adiabatic Inversion Recovery Prepared Ultrashort Echo Time (IR-UTE) Imaging of Bound Water in Cortical Bone

Shihong Li¹,², Michael Carl³, Eric Chang¹, Won C. Bae¹, Christine Chung¹, Graeme M. Bydder⁴, Jiang Du¹

¹Radiology, University of California, San Diego, San Diego, CA, United States; ²Huadong Hospital, Fudan University, Shanghai, China; ³Global Applied Science Laboratory, GE Healthcare, San Diego, CA, United States; ⁴Radiology, University of California San Diego, San Diego, CA, United States

Bone is a composite material consisting of mineral, organic matrix and water. There is mounting evidence showing that there are age and disease related changes to the organic matrix. However, there are no techniques available for direct imaging of the organic matrix in vivo. Magnetic resonance imaging (MRI) has been employed to indirectly evaluate the organic matrix via direct imaging of water bound to collagen in cortical bone. In this study we investigated the adiabatic inversion recovery prepared ultrashort echo time (IR-UTE) sequence to evaluate bone water bound to the organic matrix.