Abstract #0716

Minimizing the Influence of Blood Volume Fraction on Other Pharmacokinetic Parameters in DCE-MRI

Xin Li¹, Jeffrey M. Njus¹, Seymur Gahramanov², Csanad G. Vrallyay², John W. Grinstead³, Charles S. Springer, Jr.¹, Edward A. Neuwelt², William D. Rooney¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; ²Department of Neurology, Oregon Health & Science University, Portland, OR, United States; ³Siemens Healthcare, Portland, OR, United States

For DCE-MRI, it is possible to obtain consistent K^trans (CR transfer constant) and v_e (extracellular, extravascular volume fraction) values whether incorporating v_b (blood volume fraction) or not into DCE-MRI modeling. This often requires minimizing the influence of v_b in DCE-MRI data time-courses.