William D. Rooney1,
Sean C. Forbes2, William Triplett3, D-J Wang4,
James Pollaro1, Soren DeVos2, Rebecca J. Willcocks3,
Richard Finkel5, Barry Russman6, Barry Byrne7,
Lee Sweeney8, Glenn A. Walter3, Krista Vandenborne2
1Advanced
Imaging Research Center, Oregon Health & Science University, Portland,
OR, United States; 2Department of Physical Therapy, University of
Florida, Gainesville, FL, United States; 3Department of Physiology
and Functional Genomics, University of Florida, Gainesville, FL, United
States; 4Radiology, The Childrens Hospital of Philadelphia,
Philadelphia, PA, United States; 5Neurology, The Childrens
Hospital of Philadelphia, Philadelphia, PA, United States; 6Neurology,
Oregon Health & Science University, Portland, OR, United States; 7Department
of Pediatrics, University of Florida, Gainesville, FL, United States; 8Department
of Physiology, University of Pennsylvania, Philadelphia, PA, United States
The purpose of the study was to investigate the age dependence of MRS water proton qT2 values in healthy control boys and boys with DMD. Data were acquired from 83 DMD boys and 22 healthy controls on 3T MRI instruments at three institutions. 1H MRS data were acquired to estimate 1H2O T2 using a STEAM single voxel located in the soleus muscle. 1H2O T2 values were significantly increased for DMD boys and decreased with age. Corticosteroid treated DMD boys had a lower 1H2O T2 than untreated DMD boys.