Abstract #0660

Non-Invasive Assessment of Cardiac Metabolic Alterations Following LAD Occlusion Using Hyperpolarized 13C Imaging

Angus Z. Lau¹,², Albert P. Chen³, Yiping Gu¹, Jennifer Barry⁴, Nilesh R. Ghugre¹,², Graham A. Wright¹,², Charles H. Cunningham¹,²

¹Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; ²Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; ³GE Healthcare, Toronto, Ontario, Canada; ⁴Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada

Accurate assessment of myocardial viability early following myocardial infarction is a critical challenge in cardiology. In this study, dynamic, spatially resolved hyperpolarized 13C imaging was used to monitor longitudinal cardiac metabolic changes following AMI of different severities (45 and 90 minute LAD occlusion) in vivo in a porcine ischemia-reperfusion model. Within the region exhibiting delayed gadolinium enhancement, the 45 minute group showed a modest decrease in bicarbonate at day 2, which resolved at 7 days, while the 90 minute group showed strongly attenuated bicarbonate at both time points.