Abstract #0655

Differentiation of Pyruvate Flux Versus Exchange in Rat Liver in vivo Using a Three-Site Exchange Model

Jae Mo Park¹,², Ralph Hurd³, Kelvin Bilingsly¹, Sonal Josan,¹⁴, Yi-Fen Yen¹, Dirk Mayer¹,⁴, Daniel Spielman¹,²

¹Radiology, Stanford University, Stanford, CA, United States; ²Electrical Engineering, Stanford University, Stanford, CA, United States; ³Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; ⁴Neuroscience Program, SRI International, Menlo Park, CA, United States

We propose an improved three-site exchange model that considers conversion between pyruvate, lactate, and alanine, and measure the ratio of flux and isotopic exchange among them by injecting co-polarized pairs of [2-13C]pyruvate and [1-13C]alanine, and [2-13C]pyruvate and [1-13C]lactate.