Abstract #0615

ROI-Based Analysis of Diffusional Kurtosis Estimates for Identification of MCI-Patients at High Risk for Conversion to Alzheimers Disease in a Heterogeneous MCI Cohort

Daniel Svrd¹,², Filip Szczepankiewicz³, Jimmy Ltt², Markus Nilsson⁴, Sebastian Palmqvist⁵,⁶, Katarina Ngga⁵, Oskar Hansson⁵,⁶, Danielle van Westen¹,²

¹Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, -, Sweden; ²Center for Medical Imaging and Physiology, Skane University Hospital, Lund, Lund, -, Sweden; ³Medical Radiation Physics, Lund University, Lund, -, Sweden; ⁴Lund BioImaging Center, Lund University, Lund, -, Sweden; ⁵Clinical Memory Research Unit, Department of Clinical Sciences Malm, Malm, -, Sweden; ⁶Department of Neurology, Skane University Hospital Lund, Lund, -, Sweden

The potential of Diffusional Kurtosis Imaging (DKI) for differentiation of patients with pathological CSF (MCIp-CSF) from MCI-patients without pathological CSF (MCInp-CSF) and from controls was probed for using ROI-based analysis. Diffusivity changes were present in some areas. Kurtosis parameters MK and RK did not outperform diffusion parameters MD and FA.