Abstract #0612

Cognitive Reserve Modulates the Defaul Mode Network in Patients with MCI and AD

Marco Bozzali¹, Claire Dowling², Laura Serra³, Barbara Spano'³, Carlo Caltagirone⁴,⁵, Mara Cercignani⁶

¹Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; ²School of Life Sciences, University of Sussex, Brighton, United Kingdom; ³Neuroimaging Laboratory, IRCSS Santa Lucia, Rome, Italy; ⁴Dept of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; ⁵Dept. of NeuroScience, University of Rome "Tor Vergata", Rome, Italy; ⁶CISC, Brighton & Sussex Medical School, Brighton, United Kingdom

This paper investigates the relationship between functional connectivity of the default mode network (DMN) and "cognitive reserve", measured by education and occupation, in patients with MCI and AD. Results support the hypothesis that modulation of connectivity occurs in the posterior cingulate, one of the key nodes of the DMN.