New Approaches in B1-Mapping Compensation for in Vivo Quantitative 19F MR Molecular Imaging Using UTE BSSFP

Matthew J. Goette¹, Todd A. Williams¹, John S. Allen¹, Jochen Keupp², Gregory M. Lanza¹, Samuel A. Wickline¹, Shelton D. Caruthers¹

This study presents a strategy to more accurately quantify the sparse 19F signal from alpha-v-beta-3-integrin targeted perfluorocarbon nanoparticle emulsions with a 1H image-based Actual Flip Angle B1-mapping correction to the 19F and 1H images, acquired with a simultaneous dual-frequency ultra-short echo time balanced steady state free precession sequence, in an in vivo setting using a VX2 tumor model implanted into rabbits.