Abstract #0518

Comparison of Diffusion Kurtosis Imaging, Dynamic Susceptibility Weighted Imaging and Short Echo Time Chemical Shift Imaging for Grading Gliomas

Sofie Van Cauter¹, Diana M. Sima², Anca R. Croitor Sava², Jelle Veraart³, Stefan Sunaert¹,⁴, Sabine Van Huffel², Uwe Himmelreich⁵

¹Radiology, University Hospitals of Leuven, Leuven, Vlaams-Brabant, Belgium; ²ESAT-PSI, Department of Electrical Engineering, Catholic University of Leuven, Heverlee, Vlaams-Brabant, Belgium; ³Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium; ⁴Translational MRI, University Hospitals of Leuven, Leuven, Vlaams-Brabant, Belgium; ⁵Biomedical NMR Unit/Molecular Small Animal Imaging Center, Department of Medical Diagnostic Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium

Current routinely used MR techniques are often insufficient in accurate grading of glioma. Hence, in most cases a biopsy is warranted in order to obtain a definitive diagnosis. In this study, we assessed the diagnostic accuracy of diffusion kurtosis imaging, dynamic susceptibility-weighted magnetic resonance imaging and short echo time chemical shift imaging for grading gliomas. The most accurate parameters for determination of glioma grade were mean kurtosis and mean relative regional cerebral blood flow. However, a combination between calculated parameters could still provide a better differentiation between high- and low-grade glioma in this data set.