Abstract #0510

Image-Guided Metabolomic Analysis of 2-Hydroxyglutarate in IDH-Mutant Gliomas

Llewellyn E. Jalbert¹, Adam Elkhaled², Joanna J. Phillips³, Susan M. Chang⁴, Sarah J. Nelson¹,²

¹Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States; ²Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; ³Pathology, University of California, San Francisco, San Francisco, CA, United States; ⁴Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

2-hydroxyglutarate (2HG) has proved to be a promising biomarker for IDH1/2 mutations that can be quantified using magnetic resonance. However, little research has been conducted on the affect on 2HG on the cellular metabolome. The goal of this study was to investigate the differences in metabolic profiles between IDH-mutant low-grade gliomas containing 2HG with wild-type IDH tumors using proton High-Resolution Magic Angle Spinning (1H HR-MAS) spectroscopy of 242 image-guided tissue samples that were acquired from 110 patients with recurrent, low-grade gliomas.