1Translational
Neuroradiology Unit, Neuroimmunology Branch, National Institute of
Neurological Disorders and Stroke, Bethesda, MD, United States; 2Advanced
MRI Section, Laboratory of Functional and Molecular Imaging, National
Institute of Neurological Disorders and Stroke, Bethesda, MD, United States; 3Cerebral
Microcirculation Unit, Laboratory of Functional and Molecular Imaging,
National Institute of Neurological Disorders and Stroke, Bethesda, MD, United
States
T2* relaxation and its orientation dependence were studied in marmoset monkeys and humans at high field. Measurements were analyzed with multi-component fitting and compared to simulations to account for the organization of myelin at the cellular and molecular levels. Our findings suggest the possibility to identify myelin water, and to distinguish between axonal and interstitial water based on R2* signal decay and frequency shift (Δf) information.