Abstract #0388

Gray Matter Perfusion and Its Association with Neurocognitive Performance to Evaluate Late Effects of Cancer Treatment

Adam M. Winchell¹,², Kevin R. Krull³, Matthew A. Scoggins¹, Ralf B. Loeffler¹, Robert J. Ogg¹, Melissa Hudson³, Claudia M. Hillenbrand¹

¹Radiological Sciences, St. Jude Childrens Research Hospital, Memphis, TN, United States; ²Biomedical Engineering, University of Memphis, Memphis, TN, United States; ³Epidemiology & Cancer Control, St. Jude Childrens Research Hospital, Memphis, TN, United States

Children treated with cranial radiation for childhood leukemia are at significant risk of developing cognitive problems as are long-term survivors of Hodgkin Lymphoma treated with thoracic radiation. Examining the late effects of treatment with radiation and chemotherapy are necessary to derive effective treatment options that simultaneously minimize late effects for future patients. GLM analysis identified a significant region in the left superior temporal gyrus where resting state blood flow was correlated with FSIQ performance in Hodgkin Lymphoma survivors and not in Acute Lymphoblastic Leukemia survivors.