Three Dimensional Mapping of the Creatine Kinase Reaction Rate in Muscles of the Lower Leg

Prodromos Parasoglou¹, Ding Xia¹, Gregory Chang¹, Antonio Convit², Ravinder R. Regatte¹

In this study, we developed and implemented a novel three-dimensional 31P-MT imaging sequence that maps the kinetics of CK in the entire volume of the lower leg within acquisition times that can be tolerated by patients. We tested the sequence on five healthy and two clinically diagnosed type 2-diabetic patients. Overall, we obtained measurements that are in close agreement with measurements reported previously using spectroscopic methods. Importantly, our spatially-resolved method allowed us, in the case of diabetic patients, to detect variations of the CK rate of different calf muscles, which would not have been possible using unlocalized MRS methods.