Bryan H. De La Garza1,
Charkradhar Velagapudi2, Hanna E. Abboud2, Guang Li3,
Timothy O. Duong4
1Ophthalmology/Radiology
, Research Imaging Institute, Univ. of Texas Health Science Center at San
Antonio, san antonio, tx, United States; 2Division of Nephrology, Department
of Medicine, Univ. of Texas Health Science Center at San Antonio, San
Antonio, tx, United States; 3Ophthalmology/Radiology, Research
Imaging Institute, Univ. of Texas Health Science Center at San Antonio, san
antonio, tx, United States; 4Ophthalmology/Radiology, UT Health
Science Center at San Antonio, san antonio, tx, United States
This study used high-resolution manganese-enhanced MRI (MEMRI) to investigate the manganese uptake in different layers of the retina of diabetic retinopathy (DR) rats under light and dark adaptation. In normal rats, dark adaption lowered inner retina MEMRI activity, increased outer retina activity, and did not affect the choroid compared to light adaptation. In DR rats compared to controls, MEMRI revealed significant reduced Mn uptake in all three (inner, outer, and choroid) retinal layers. Differential reduced MEMRI activity in the dark in the outer layer in DR rats compared to control animals, suggesting outer retina dysfunction at early DR.