Yash Vardhan Tiwari1,
Fang Du1, Qiang Shen1, Timothy O. Duong2
1Research
Imaging Institute, University of Texas Health Science Center at San Antonio,
San Antonio, TX, United States; 2Research Imaging Institute, UT Health
Science Center at San Antonio, San Antonio, TX, United States
We used quantitative MRI to longitudinally evaluate the effects of normobaric hyperoxia (NBO) treatment on the outcome of ischemic stroke in rats. The major finding is that NBO treatment decreased infarct size by 27.4 % compared to control at day 2. NBO treatment stopped ADC lesion growth at the acute phase, thereby delaying the progression of ischemic penumbra to ischemic core. With reperfusion, substantially more tissue was salvaged compared to controls. The implication of these findings is that NBO can be used to buy time and expand the treatment time window in stroke patients