Abstract #0335

A Modified Photothrombotic Stroke Model Using Implantable Optic Fiber: In-Bore Stroke Induction for Probing Peri-Infarct Spreading Depolarization

Yu-Chieh Jill Kao¹, Hsin-Yi Lai¹, Chris Kao¹, Yen-Yu Ian Shih¹

¹Experimental Neuroimaging Laboraory, Department of Neurology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, Chapel Hill, NC, United States, Chapel Hill, NC, United States

A photothrombotic stroke model using implantable optic fiber (IOF photothrombosis) was proposed in rats to visualize ADC and CBF changes before, during and after stroke onset. Peri-infarct spreading depolarization (PID) and post-PID oligemia were demonstrated for the first time by high resolution diffusion/perfusion MRI. IOF photothrombosis is highly feasible to create ischemic lesion in predetermined brain area with well-controlled infarct size, which opens up new avenues for preclinical stroke research.