Abstract #0332

Resting-State MRI Detects Donepezil Effects on Functional Connectivity and Maze Learning in Rodent Brain

Fatima Ali Nasrallah¹, Xuan Vinh To¹, Tovia Yun Jie Ng¹, Kai-Hsiang Chuang¹

¹Magnetic Resonance Imaging Group, A*Star Biomedical Research Institutes, Singapore, Singapore

Functional connectivity MRI has emerged as a means to map intrinsic brain networks without the need of explicit tasks. We investigated the effects of Donepezil on brain function using Atlantis Watermaze and functional connectivity MRI. Donepezil is a popular treatment for improving cognitive function in Alzheimers disease patients. We show that the alteration of the functional connectivity pattern after donepezil treatment is closely associated with cognitive improvement.