Abstract #0227

Apparent Diffusion Coefficient Decrease During Thermal Ablation of the Prostate as an Early Indicator for Loss of Tissue Viability.

Juan C. Plata¹, Andrew B. Holbrook¹, Michael Marx¹, Vasant Salgaonkar², Peter Jones², Chris J. Diederich², Aurea Pascal-Tenorio³, Donna Bouley³, Graham Sommer⁴, Kim R. Butts Pauly⁵

¹Radiology, Stanford, Stanford, CA, United States; ²Radiaiton Oncology, University of California San Francisco, San Francisco, CA, United States; ³Comparative Medicine, Stanford, Stanford, CA, United States; ⁴Clinical Radiology, Stanford, Stanford, CA, United States; ⁵Radiology, Stanford University, Stanford, CA, United States

Diffusion weighted MRI (DWI) has demonstrated a 36% reduction in apparent diffusion coefficient (ADC) following HIU induced tissue damage of the prostate. We have previously used interleaved temperature and ADC measurements to extract tissue viability information from ADC measurements that are also dependent on temperature. Our purpose is to demonstrate that the decrease/plateau of ADC during sonication of the prostate was indicative of a transition from viable to non-viable tissue. We monitored treatments on healthy tissue as well as previously damaged tissue to assess whether our proposed marker of tissue viability is reliable and agrees with histology.